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Some heroin users may take them either to supplement their drug or to substitute for it.Stimulant users may take sedatives to calm excessive jitteriness.

Sedatives can be misused to produce an overly-calming effect (alcohol being the classic and most common sedating drug).

They increase tractability and compliance of children or troublesome or demanding patients.

Some sedatives can cause psychological and physical dependence when taken regularly over a period of time, even at therapeutic doses.

Sedatives and alcohol are sometimes combined recreationally or carelessly.

Since alcohol is a strong depressant that slows brain function and depresses respiration, the two substances compound each other's actions and this combination can prove fatal.

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